With deep sadness I have learned of the departure of Prof. Martha Eibl, my adored teacher and mentor. She was the person that attracted me to a carrier in immunology and gave me utmost inspiration for a life-long interest in basic science. The combination of clinical work and research successfully determined her life and was model for many others to come. Prof. Martha Eibl was an excellent and multiple awarded physician-scientist and an inspiration to team up with. Her dedication to unravel mechanisms of human primary and secondary immunodeficiencies is legendary. More than this, she has contributed to an improvement in diagnosis and treatment of immunodeficiency, has set up a Clinic to treat affected individuals, knowing that a perfect management of disease can prolong life and has started a company to develop vaccines and processes in biomedicine. At the personal level, I have had the privilege to collaborate with her extensively over a period of more than thirty years with great highlights in the field of immunology and far beyond. Next to clinical immunology and basic science we loved arts, literature and music and shared h ours of intensive debate after work or while joining national- and international meetings. She will be missed as an unwaveringly visionary scientist equipped with empathic dedication to her patients and those that needed help. In this respect she was admired by all her colleagues and friends. I am sure her legacy will live on.